Season 5: Episode 8
After Martha (Annette O'Toole) contracts a strange disease and is given hours to live, Clark (Tom Welling) turns to Professor Fine (guest star James Marsters), who convinces Clark that Jor-El is the one responsible for her illness and the only way to save her is to destroy the Fortress of Solitude. However, once the two arrive at the Fortress, Professor Fine tries to free Zod and kill Clark.

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