Nathan walks into Imperial Valley Bank in Juan, California, a desert town, with Judge Roy, a corrupt, egocentric, and completely inappropriate man. The judge hands Nathan a briefcase full of thousands of dollars after what seems like a very long courtship. Nathan has been running a con on him for two weeks—Roy thinks they’ve set up a money laundering scam, but Nathan intends to bankrupt him. To help him, Sophie has been playing the part of a banker. Across the street in a sweltering van, Hardison complains about agreeing to do a “rip deal.” He thinks they take too long, especially when it has to take place in a town hotter than hell in the middle of nowhere. Parker, who likes Juan, calmly explains that it takes a long time to convince the mark that he’s getting deal so that they can then rip him off. She lights what looks to be pages from a ledger on fire. When Hardison places a call to Eliot to confirm that he’s shutdown all of their fake addresses and p.o. boxes, it becomes clear that they’re all destroying evidence of ever having worked in Juan.

Dr. Kelso's beautiful replacement, the unethical Dr. Maddox (guest star Courteney Cox), shakes things up a bit, while J.D. struggles to manage new interns.

J.D. and Turk set aside their decade long steak night tradition to comfort a dying patient, while Dr. Maddox (guest star Courteney Cox) begins to show her true colors.

In the aftermath of the tornado, the residents of Wisteria Lane try to rebuild their lives. Katherine discovers someone may know her secret while Lynette faces the possibility of her family's fate. Meanwhile Mrs. McCliskey has to face the death of one of her dearest friends, Ida.

Much to the Comic Book Guy's chagrin, Bart, Lisa and Milhouse check out a new comic book store called Coolsville, where they are treated like royalty by a friendly comic book buff named Milo (guest voice Jack Black). Coolsville attracts some real-life comic book creators, such as Alan Moore, Art Spiegelman and Dan Clowes (guest-voicing as themselves), and the Comic Book Guy wages war on Coolsville in an attempt to win back his customers. Meanwhile, Marge decides her middle-aged physique could use some help, and she launches a gym for "regular women." Marge's gym becomes wildly successful and as her fame grows, Homer fears she will dump him for a younger, more fit guy. Homer decides to take matters into his own hands to get into shape.

As McNulty and the detail continue to stake out Marlo's crew, recently promoted Sgt. Carver is welcomed by a cauldron of discontent from officers coping with unpaid overtime; Though he wants to keep his campaign promise to lower crime, Mayor Carcetti is strapped by his commitment to schools, and faces some tough choices; Col. Daniels is forced to reallocate his resources, retaining Freamon and Sydnor for the Clay Davis probe; Meanwhile, city editor Augustus "Gus" Haynes and the staff of The Baltimore Sun are reeling from corporate cutbacks, losing key personnel from both the metro and international divisions; Still, with the help of reporters Alma Gutierrez, Jeff Price and Scott Templeton, Haynes is able to break a front-page story that links a politician to a co-op drug dealer; Proposition Joe, Marlo, Fatface Rick and other New Day Co-Op members meet in a hotel conference room to discuss divvying up drug frontiers across East Baltimore's county line.

Serena (Blake Lively), Blair (Leighton Meester), Nate (Chace Crawford), Chuck (Ed Westwick) and their entourage break into the school swimming pool for a night of fun, but when a member of their group nearly drowns, the school threatens to expel the person responsible for the break-in. Everyone agrees to keep a secret pact and say nothing, but it ultimately creates major tension between Serena and Dan (Penn Badgley), who isn’t sure he’s ready to take the fall for someone else and risk his future. Vanessa (Jessica Szohr) is working on a documentary project about private schools and accidentally captures Blair and Chuck discussing their affair. Lily (Kelly Rutherford) contemplates telling Rufus (Matthew Settle) how she really feels about him. Taylor Momsen also stars. The episode was directed by Tony Whamby and written by Lenn K. Rosenfeld.

Four years after the season four finale, Tree Hill is a new place. Lucas (Chad Michael Murray) is a struggling writer who is about to embark on a new coaching career with Skills (Antwon Tanner). Peyton (Hilarie Burton) is at the beginning of a budding music venture, while Brooke's (Sophia Bush) fashion line is at a crossroads.

Meanwhile, Nathan (James Lafferty) and Haley (Bethany Joy Galeotti) are young parents trying to find their way. Much has changed in four years, but in many ways, the journey is just beginning.

Mike must stop the spread of a nanovirus that infects KITT and threatens total global meltdown.

Things get tense as Lynne meets the wives and Gretchen is offended by Tamra.

When a tornado hits a rival high school, the Panthers share their facilities and chaos erupts.