Seth Rogen, Jonah Hill, Anne Hathaway, Jackie Mason, Neve Campbell and the late Eartha Kitt are among the guest voices on the upcoming 21st season of The Simpsons airing Sundays (8:00-8:30 PM ET/PT) on FOX.

In "Homer The Whopper," the season premiere episode co-written by Seth Rogen airing Sunday, Sept. 27, "Comic Book Guy" casts "Homer" as the lead in "Everyman," a feature film based on the new comic book superhero he created. To whip Homer into superhero shape, the movie studio hires celebrity fitness trainer "Lyle McCarthy" (guest voice Rogen), but Homer has trouble sticking to his new healthy regimen.

Jonah Hill guest-voices as "Andy," a former Springfield Elementary student hailed as the best prankster ever in the upcoming episode, "Pranks and Greens." Neve Campbell plays "Cassandra," a Wiccan accused of blinding the town with a spell (a la "The Craft") in "Rednecks and Broomsticks." Jackie Mason returns as Rabbi Krustofsky, Krusty the Clown's father, in "Once Upon a Time in Springfield," in which Krusty ends up falling in love with the actress who plays "Princess Penelope" (guest star Anne Hathaway), a new character on his show. The late Eartha Kitt also lends her voice talents to the episode.

Additional guest stars paying Springfield a visit next season include Coldplay's Chris Martin, Sarah Silverman, football greats Eli Manning and Peyton Manning, sportscaster Bob Costas, UFC champion Chuck Liddell and actress Angela Bassett.

January 14, 2009 kicked off the "Best. 20 Years. Ever.," a year-long global 20th anniversary celebration of all things The Simpsons. The year will conclude with The Simpsons 20th Anniversary Special - IN 3-D! on Ice! produced and directed by Academy Award-nominated filmmaker Morgan Spurlock (Super Size Me, 30 Days).

The Simpsons is a Gracie Films Production in association with 20th Century Fox Television. James L. Brooks, Matt Groening, and Al Jean are the executive producers. Film Roman, a Starz Media company, is the animation house.