"I'm just starting to talk to Sony about it," Anderson said. "I don't even know if anything will come of it, but there's a possibility it might happen."
Anderson did say that coming up with another story is what is hindering the film's development process.
"I love the 'Resident Evil' franchise and we always try to make the best possible movie we can. If we could find a good Resident Evil 4 to make, then we would do it," he said. "But I wouldn't just do it for the sake of it, that's for sure."
The first three films grossed $379 million combined worldwide and were also solid performers on DVD.
Resident Evil: Afterlife was released September 10th, 2010 and stars Milla Jovovich, Ali Larter, Kim Coates, Shawn Roberts, Sergio Peris-Mencheta, Spencer Locke, Boris Kodjoe, Wentworth Miller. The film is directed by Paul W.S. Anderson.