The sequel would be a comeback for both the actor and the director, since Grodin has only appeared in one film (The Ex) since 1994 and Brest hasn't directed a film since the 2003 bomb Gigli. The site confirmed with Robert De Niro's Tribeca Films that they are pursuing both Grodin and Brest.
"I've been led to believe by someone I won't name that they will ask me and I will consider it," Grodin told the site. Here's another excerpt from the site.
"I just turned down the new Muppet movie," Grodin told me Tuesday. "I was in The Great Muppet Caper and I think they are bringing back those of us still alive for a reprise. Jim Henson was dear to me but I'm not flying 6000 miles to Los Angeles to work one day."
Grodin left the acting life to raise his son in the early 90s and now lives in Connecticut, although it seems he's considering returning for the sequel. We'll be sure to keep you posted on any further details on the Untitled Midnight Run Sequel as soon as we have more information.