John C. Reilly, Jonah Hill and Marisa Tomei will star in an untitled Mark and Jay Duplass comedy for Fox Searchlight.

According to Variety, the Duplass brothers will make their studio directing debut on the pic, formerly known as "Safety Man," from a script they penned.

The story centers on a recently divorced man (Reilly) who meets the woman of his dreams (Tomei). She has a teenage son (Hill) who has no interest in sharing his mother with a new man.

Scott Free's Michael Costigan is producing.

Production will begin in January.