Weekend Box Office:

1)Dr. Seuss' Horton Hears a Who $45.1 million

2)10,000 B.C. $16.4 million

3)Never Back Down $8.6 million

4)College Road Trip $7.8 million

5)Vantage Point $7.8 million

6)The Bank Job $4.9 million

7)Doomsday $4.7 million

8)Semi-Pro $3 million

9)The Other Boleyn Girl $2.9 million

10)The Spiderwick Chronicles $2.3 million

Dr. Seuss' Horton Hears a Who proved to have the biggest box office opening of not only this weekend, but of 2008 thus far. The Fox animated adaptation of the 1954 Suess classic roped in a healthy $45 million, high above industry expectations. The film, voiced by Jim Carey and Steve Carell, is the fifth biggest grosser in animated, G rated history. This can mean only one thing: A full-length theatrical adaptation of Green Eggs and Ham isn't very far off in the future.

Last week's 10,000 B.C. came limping into second place with a paltry $16.4 million, though it made double that of its third place competitor Never Back Down. The high-kicking kiddy Fight Club only managed to scrap $8 million worth of ticket sales together, but that was enough to make it a modest hit for Summit releasing. We will most likely see a sequel to this Karate Kid wannabe sometime in the near future.

Doomsday, the week's only other major release, hit with a thud in seventh place earning an estimated $4.7 million. On the indie front, Funny Games took in $520,000 on 289 screens, while the drama Sleepwalking raked in just under $50,000 on 30 screens.

Next week, Horton and the Mayor of Who-Ville will have to face down the behemoth Tyler Perry's Meet the Browns as well as Shutter, Drillbit Taylor, and The Grand.

Dr. Seuss' Horton Hears a Who was released March 14th, 2008 and stars Jim Carrey, Steve Carell, Carol Burnett, Will Arnett, Seth Rogen, Dan Fogler, Isla Fisher, Jonah Hill. The film is directed by Jimmy Hayward, Steve Martino.