MTV Splash Page recently got to speak with
Spider-Man 4 director Sam Raimi, who talked about the film's villain. While he didn't reveal exactly who the villain would be in the film, he did talk about how they were approaching the villain, which you can see below.
"What we're trying to do right now is really understand the journey Peter is going to go on this time and have the villain maybe be a counter to that growth, something that he has to overcome," Raimi said. "Or maybe he has to grow in a way to overcome the villain, because there always seem to be stories of coming of age, of a young man growing up and learning things about life, so once we are identifying the exact movement that Peter has to grow to, I think the villain-and we're trying this right now; we're trying to choose a villain based on who would be the proper counter to that growth, so we really have dramatic conflict."

for the rest of the site's article on Raimi.
Spider-Man 4 is currently gearing up for a March 2010 shooting date and a May 5, 2011 release date.
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[Sidenote: Only because Sam decided to make the film about "forgiveness," which BTW I saw no motivation or even any slight hint of inspiration as to why Parker would want to forgive and forget this guy. I mean, they twisted up the story of Uncle Ben's death (which was a guilt trip for Peter to begin with and sunk so deep into his being that it made him fight crime nonstop), and threw in this guy, the Sandman, and then in the climax, "oh, wait, no, its okay - you can leave, I forgive you." HUH??!? Why do you forgive him? Cuz his daughter from one scene who you don't know personally is supposedly sick? Nah, dude, he killed Uncle Ben! He's a criminal, and you are a do-gooder, throw him in a jail cell where he belongs!]
Anyways, enough Sam- and "Spider-Man 3"-bashing, I agree with a comment written before, about how Sam Raimi realizes the mistakes of "3" and is listening to the fans, hopefully. Yes and I am absolutely sure within my mind that The Lizard will be a main spectacle of "Spider-Man 4," and I heard unofficially that the studio wanted two villains, but we will see what turns out, what Raimi wants to do with "4." I personally don't feel that the film can be carried by The Lizard as the only villain throughout the film. Like a whole film about how Dr. Curt Connors has to battle with becoming The Lizard, and Parker has to take his mask off a bunch of times to connect with him emotionally (LOL, I guess I just know Raimi), I feel it would need a Villain #2.
Though regarding the third film, I would have liked it if it was planed better. Making the 3 and 4 being connected, as Sandman exits from the 3rd and Peter help Harry out get passed his anger.
As they did, but things didn't pan out as it should since Venom showed up which did ruin the film a bit or more.
The fourth should be about Venom period, without that little kid from the 70"s Show as Peter now has to deal with a crazy alien.
If Venom never entered the picture I bet it would have been better and there was too much romance involved.
As I said above Venom should be the focus and introduce another villain at the end.
The one thing I liked about Batman Begin is Jokers calling card, Sam needs to start using this angle a little more.
The death of these villains needs to stop, personally I want to see them again.
that will definately work
but then again the villians would probably fight with eachother
until they realize that they can team up to beat him
And Sony did want to bring back venom and do him justice.
But as said no confirmation yet, just speculation by people trying to read behind the lines of the news updates on the film and of course who'd they'd like to see as well in future installments.
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The info on it
Well the review never stated who the villain was, but rumour began flying that the villain was the symbiote itself.
Which does make logical sense, in terms of writing and of course 2-part.
I read that Vanderbilt's 2 part story draft for spiderman 4 & 5 involved Lizard, Kraven, Carnage & Venom. In which if the villain is the symbiote it all makes real logic sense, in terms of the universe of Spidey and writing a story that spans 2 films.
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How i see it happening story wise
Lizard story goes as we all know and well, in one transformation the symbiote is freed, that opens the door for venom and carnage but they are left as a cliffhanger for this movie.
Once spidey finds out who lizard is, he cant bring himself to destroy him and tries to help him control his dark evil amphibian inner beast, so Kraven comes to do what Spidey can't (Thus following 'The Hunt' story arc).
A final battle commences but the symbiote is still attracted and determined to attach itself to its original host Peter Parker aka Spiderman, in the finale, the symbiote splits in 2 and one part gets the blood of Spidey man in it, which turns it red.
So we now have 2 symbiotes, the black one leaps on to Peter, bringing out the darker Spidey. As dark spidey battles his inner self and Kraven and Lizard duke it out, one of them ends up dying preferably Kraven, Symbiote is thrown off Spidey and cowers to the sewers, news report that Cletus Cassidy has just escaped, during the report of Dr Connors stating that he has found a cure and he is back to normal.
That is technically Spiderman 5 set up beautifully, and brings back Venomn and introduces Carnage.
Sam Raimi isn't confirmed for Spiderman 5 or 6.
He stated that himself in an interview