Rosario Dawson and Woody Harrelson are in final negotiations to star alongside Will Smith in Columbia Pictures drama Seven Pounds, according to Variety.

The Grant Nieporte-written screenplay centers on a guilt-ridden man who inadvertently falls in love while attempting to kill himself. Dawson will play a love interest who suffers from a serious heart condition. Harrelson will portray a motel attendant who becomes intrigued by his suicidal new tenant.

The Pursuit of Happyness helmer Gabriele Muccino will direct the film.

Shooting is scheduled to begin in February for a late 2008 release.