The film Marley & Me has just locked its two main leads. According to Variety, Owen Wilson and Jennifer Aniston will pair up for the theatrical adaptation of John Grogan's best selling memoir.

The book told the story of the mischievous Labrador retriever Marley, who was adopted by Philadelphia Inquirer columnist Grogan and his wife. They had gotten the dog as a tester for parenthood, but the rambunctious pooch proved to be a handful. The dog tore the house apart, got kicked out of obedience school, and started to misbehave when the baby arrived. Yet, despite all of the dog's problems, she became an indispensable member of the family.

David Frankelis directing the script by Scott Frank. The film is set to go before the camera early next year for a 2009 release date.