One Last Thing... tells the story of 16 year-old Dylan Jameison (Michael Angarano) who has terminal cancer. When the charitable organization United Wish Givers grants Dylan a last wish, he initially chooses to go fishing with his football hero, Jason O'Malley (Johnny Messner). In a moment of inspiration during the locally televised news conference, Dylan changes his mind and reveals that his actual final wish is to spend a weekend with the supermodel Nikki Sinclair (Sunny Mabrey), whose poster hangs proudly above his bed.
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