On November 26, 1956, Fidel Castro sails to Cuba with eighty rebels. One of those rebels is Ernesto "Che" Guevara, an Argentine doctor who shares a common goal with Fidel Castro - to overthrow the corrupt dictatorship of Fulgencio Batista.

After the Cuban Revolution, Che is at the height of his fame and power. Then he disappears, re-emerging incognito in Bolivia, where he organizes a small group of Cuban comrades and Bolivian recruits to start the great Latin American Revolution.