Along with Clark Gregg, Marvel's S.H.I.E.L.D. stars Ming-Na as Agent Melinda May, Elizabeth Henstridge as Agent Gemma Simmons, Ian De Caestecker as Agent Leo Fitz, and Brett Dalton as Agent Grant Ward. The series is set within the S.H.I.E.L.D. organization, but will not include any of the superheroes from Marvel's The Avengers.
With that being said, Samuel L. Jackson, who played S.H.I.E.L.D. leader Nick Fury in Marvel's The Avengers, recently revealed he would like to reprise his role for the series.
Only time will tell if Samuel L. Jackson (or just his voice} will be included in this potential new series.