This is what Mike Mignola had to say about the non-existent possibilities of another Hellboy sequel ever being directed by Guillermo del Toro.
"Last I heard he said he would not make it. Guillermo -- who I love -- in every interview there's a new story on what his next movie is and he honestly believes he's going to do all these things. But last I heard, he said 'I'm never gonna get back to Hellboy. I'm not surprised because he won't live long enough to do a tenth of the movies he's told me he's going to make. I can't imagine him making a Hellboy 3. He's very enthusiastic and says he's going to do all these things....ummm....he's cute [laughed]."
Guillermo del Toro's next movie will be Pacific Rim. It is not known at this point if another director will take over the Hellboy franchise, or if it is officially kaput.
Hellboy II: The Golden Army was released July 11th, 2008 and stars Ron Perlman, Selma Blair, Doug Jones, John Alexander, James Dodd, Seth MacFarlane, Luke Goss, Anna Walton. The film is directed by Guillermo del Toro.